安妮·兰兹伯（艾玛·斯通饰）与欧文·米尔格里姆（乔纳·希尔饰）这两个陌生人因各自不同的原因，受一项神秘药物后期试验所吸引，声称可以修复心智方面的各种疑难杂症，包括心理疾病和极度伤心。这吸引了这两人和其他十位陌生人加入 Neberdine 制药生物科技（Neberdine Pharmaceutical and Biotech），参加为期三天的药物试验。这项试验承诺受试者不会出现并发症或任何副作用，并可以根除他们的所有问题。但往往，事情不会按照计划如愿进行……
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